Dr. Hande Schmidt

Managing translational cancer research projects with a funding volume of more than 300K Euro, investigating the molecular basis of pancreatic cancer and the development of drugs for pancreatic cancer immunotherapy Mentoring and training PhD, MSc, medical students and technicians on translational cancer research, review of study protocols, troubleshooting, data analysis, data presentations in professional format and transformation of data into actionable insights

The regulation of mammalian circadian rhythm by peptidyl prolyl isomerases is elucidated at the molecular level through biophysical, biochemical methods and complemented with cell based assays. We revealed a potential functional fine tuning mechanism in a protein as a proof of concept which was selected to be the cover paper of Mol. Cell in May 2015 issue.

Identification and characterization of novel components of circadian clock by high-throughput luciferase screening The crosstalk of metabolism and circadian rhythm has recently been revealed by utilizing metabolomics, wide variety of protein-protein interaction methods along with in vivo studies. Our manuscript is submitted to Nature Metabolism in January 2019.

Investigated structure and function relationship of mammalian Cryptochrome Developed novel label-free DNA repair assay by using Surface Plasmon Resonance (SPR) Bacterial genome library for yeast two hybrid screening

Improved heat stability of a fungal lipase to 70oC by applying a directed evolution method Worked in a European 6th framework project ‘SOPHIED’ by purifying and characterizing novel laccase for dye degradation and novel pigment production for color industry