Dr. Yusuf Tanrikulu

Process owner of signal management processes and systems as required by pharmacovigilance legislation, ensuring effective safety risk assessment and appropriate benefit-risk evaluations for clinical and post-marketing products.

Management of signaling systems within the adverse event database of Global Drug Safety, compliant with FDA Good Pharmacovigilance Practices, ICH topics, and EU GvP Module IX Signal Management. Providing qualitative and quantitative periodic safety outputs using disproportionality analysis of company products vs MedDRA terms based on MGPS and PRR. Interfacing medical and technical departments to harmonize mutual understanding and efficient collaboration to provide PSUR and RMP reference data.

Computational chemistry support in CNS drug discovery projects and drug repurposing. Scientific data mining and information management in databases and unstructured files. Cheminformatics application design, development, rollouts, and support governance. User trainings and publishing of scientific results. Maintenance of high-performance cluster environment.

Analysis of bioactivity data of in vitro screening panels. Binding prediction based on activity profiles. Analysis of sparse bioactivity matrices. Application and development of innovative visualization techniques.

Development of an intranet server to provide computer-aided drug discovery tools to pharmacy and chemistry departments with a web-based user interface.

Cheminformatics, Drug Design, Drug Development, Molecular Modeling, Computational Chemistry, Programming, Scientific writing, Teaching, Supervising.

Chemieinformatik, Computerchemie, Pharmacophore-based molecular descriptors, surface- & shape-based virtual screening, machine learning, pseudoreceptor modeling.

Bioinformatics, Biology, Computer Science, Chemistry and Genetics